This educational activity addresses the high prevalence of depressive disorders among patients with cancer—a rate significantly higher than in the general population and frequently underrecognized in clinical practice. Participants will learn to identify depressive symptoms, understand the impact of untreated depression on cancer outcomes, and apply evidence‑based treatment strategies. Psychopharmacological interventions, cognitive behavioral therapy, psychotherapy, and mindfulness‑based therapies have demonstrated efficacy in reducing anxiety and depressive symptoms. Effective treatment improves adherence to cancer therapies, enhances quality of life, and supports faster recovery. This activity equips clinicians with the skills to recognize, assess, and manage depression in oncology settings or appropriately refer patients for specialized psychiatric care.