Join TeleSpecialists TeleNeurologist Sam Saha, MD as he shares details about the latest clinical trials supporting imaging-guided thrombolysis and thrombectomy decision-making that have demonstrated net benefit in subsets of patients with unknown onset of symptoms, most commonly after waking up. With wider implementation of advanced imaging augmented by artificial intelligence software, there is an argument for pushing stroke treatment boundaries long established by clinical decision-making alone. Will expanding the thrombolysis treatment window truly move the needle forward in stroke intervention, or prove to be narrowly applicable, risky, and impractical when implemented outside of large stroke centers?