Thrombolytics options have grown from just alteplase to include tenecteplase which some centers have adopted while others haven't. While both medications are similar, there is growing evidence that there are quite a few differences in administration, monitoring, and indications for medication use. This new introduction has fractured practice habits between different providers and caused growing uncertainty about how to utilize these medications to the best of their abilities. Join TeleSpecialists neurologist Dr. Igor Malenky as he reviews the use of thrombolytics for acute ischemic stroke.